PresentationLadies and gentlemen, please stand by. Ladies and gentleman, please remain on line, your conference will begin shortly.I would now like to hand the conference over to your speaker today, Ramses Erdtmann, President and Chief Operating Officer. Please go ahead.Ramses ErdtmannCo-Founder, President, COO & Director Perfect. Okay. All the other speakers that have dialed in, we're going to go live. Maybe you can let Juan Pablo now. Okay. Thank you, operator, and welcome, everyone, to this conference ca ...

会议基本信息 - 本次会议为Biomea公司电话会议 [3] - 会议由公司总裁兼首席运营官Ramses Erdtmann主持 [1][3] 临床研究进展 - 公司公布了COVALENT-111研究的52周结果 [3] - 该研究是一项随机双盲、安慰剂对照的二期临床试验 [3] - 试验旨在评估icovamenib在二型糖尿病患者中的安全性和耐受性 [3] - 试验同时包含探索性疗效终点 [3]

Biomea Fusion Inc‘s (NASDAQ:BMEA) stock price plummeted after the company priced its public offering. The public offering includes 11.2 million shares of common stock and accompanying warrants to purchase an equal number of shares. Certain investors will receive pre-funded warrants for up to 1 million shares, with warrants to purchase an additional 1 million shares. The offering also includes a 30-day option for underwriters to purchase up to 1.83 million additional shares and warrants. The common stock and ...

Biomea Fusion (NasdaqGS:BMEA) Update / Briefing October 07, 2025 08:30 AM ET Company ParticipantsMitch Hitchcock - Interim CEOSteve Morris - Chief Medical OfficerRamses Erdtmann - President and COOConference Call ParticipantsEdward Tenthoff - AnalystMatt Biegler - AnalystYigal Nochomovitz - AnalystJoe Pantginis - AnalystCha Cha Yang - AnalystOperatorGood day, and thank you for standing by. Your conference will begin momentarily. We do appreciate your patience. Please stand by.Ramses ErdtmannDo we have backg ...

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COVALENT-111 Phase II Study Icovamenib in Type 2 Diabetes 52-Week Results October 7, 2025 COVALENT 111 - 52 Week Follow Up Conference Call October 7, 2025 1 Legal Disclaimer & Forward-Looking Statements Certain statements in this presentation and the accompanying oral commentary are forward-looking statements. These statements relate to future events or the future business and financial performance of Biomea Fusion, Inc. (the "Company") and involve known and unknown risks, uncertainties and other factors th ...

Biomea Fusion (NASDAQ:BMEA) shares rose after reporting positive results from its mid-stage study testing icovamenib in individuals with type 2 diabetes over a 52-week period. The stock closed up 24% on Monday. The study found that icovamenib provided lasting treatment ...

Icovamenib showed a sustained treatment benefit at Week 52 (9 months past the end of treatment) in the severe insulin-deficient diabetes patient population taking one or more antihyperglycemic medications at baseline, with a 1.8% placebo adjusted mean reduction in HbA1c (Arm B)Type 2 diabetes patients on a GLP-1-based therapy failing to achieve their target HbA1c also showed a clinically meaningful response from only 12 weeks of icovamenib treatment with a mean placebo adjusted HbA1c reduction of 1.8% (Arms ...

SAN CARLOS, Calif., Oct. 01, 2025 (GLOBE NEWSWIRE) -- Biomea Fusion, Inc. (“Biomea” or the “Company”) (Nasdaq: BMEA), a clinical-stage diabetes and obesity medicines company, today announced that on September 24, 2025, the compensation committee of Biomea’s board of directors granted one new employee non-qualified stock options to purchase 48,000 shares of the Company’s common stock. The shares underlying each employee’s stock options will vest 1/16 on a quarterly basis over four years, subject to such empl ...

核心观点 - Biomea Fusion在2025年欧洲糖尿病研究协会年会上公布其研究性menin抑制剂icovamenib与semaglutide联合疗法的临床前数据 显示该组合在2型糖尿病动物模型中显著改善血糖控制和体重减轻 同时保留瘦体重[1][2][3] - 公司计划在2025年下半年启动icovamenib与GLP-1疗法联合的II期临床研究 并已获得下一代口服GLP-1受体激动剂BMF-650的新药研究申请批准 预计2026年上半年公布28天减肥数据[5][6][8] 临床前研究结果 - 在ZDF大鼠模型中 icovamenib(200 mg/kg 每日口服)与低剂量semaglutide(0.02 mg/kg 每日皮下注射)联合治疗28天 相比单独使用semaglutide表现更优:空腹血糖降低60% 口服葡萄糖耐量试验血糖曲线下面积降低50% 糖化血红蛋白在第28天降低超过1%[7] - 联合治疗使体重多减少约10%(-12.5% vs -3.4%) 且完全由脂肪减少驱动 瘦体重得到完全保留 同时胰岛素抵抗指标HOMA-IR降低75% β细胞功能显著改善[7] 产品管线进展 - icovamenib作为口服生物可利用的强效选择性menin共价抑制剂 通过促进β细胞增殖、保存和再活化 有望成为首个改变1型和2型糖尿病疾病进程的疗法[11] - BMF-650作为研究性口服GLP-1受体激动剂 已获得FDA新药研究申请批准 肥胖适应症的I期临床试验按计划进行中[6][8] 糖尿病市场背景 - 美国约有3700万糖尿病患者(占总人口11%) 9600万成年人处于糖尿病前期 糖尿病医疗支出占美国医疗总费用的四分之一[10] - 功能性β细胞质量和功能丧失是糖尿病核心病理特征 menin抑制可能通过解除对β细胞更新的抑制 实现正常健康β细胞的再生[9] 公司定位 - Biomea Fusion为临床阶段糖尿病和肥胖药物公司 专注于开发口服小分子药物icovamenib和BMF-650 旨在显著改善糖尿病、肥胖和代谢疾病患者生活[12]