Thank you for reading my research on Seeking Alpha. If you want to learn even more about my method and how I discover these investment opportunities, please check out my subscription marketplace service, Compounding Healthcare , and sign up for a free trial.It has been over two months since my last IQVIA Holdings Inc. (NYSE: IQV ) article , where I covered the company’s Q1 earnings beat thanks to $3.83B in revenue, driven by growth in the Technology & Analytics Solutions (TAS) segment. I pointed outHe is th ...

纪要涉及的公司和行业 - **公司**：ABIVAX（ABVX）[1] - **行业**：制药行业，专注于溃疡性结肠炎治疗领域 [6] 纪要提到的核心观点和论据 试验概况 - **试验规模**：ATTeX试验是全球性项目，在36个国家的600多个临床点开展，历时30个月，招募1275名患者 [6] - **患者类型**：涵盖初治患者和对先进疗法反应不足的患者 [6] 治疗效果 - **高疗效**：50毫克剂量显示出高度显著且具有临床意义的疗效，安慰剂校正缓解率达16.4%；25毫克和50毫克剂量组在与安慰剂对比时，FDA主要终点有21.4%和19.3%的统计学显著差异；EMA共同主要终点在两剂量组均达到，有高度统计学显著差异 [7][12] - **多终点达标**：关键次要终点如内镜改善、临床反应和组织学内镜黏膜改善等在两剂量组大多达到，且有高度统计学显著p值 [13] - **剂量响应**：各终点均观察到明显的剂量响应 [14] 安全性 - **良好安全**：最终数据库锁定预计8月完成，超95%已完成，整体安全状况良好，无新的安全信号；治疗相关不良事件导致的停药率低，与安慰剂相似；未观察到恶性肿瘤、严重或机会性感染信号；头痛是最常见不良事件，发生率和停药率低于2b期试验，且为短暂性，中位持续时间少于一周 [16] 治疗优势 - **独特机制**：obafasimod是治疗中重度活动性溃疡性结肠炎的首创新机制药物，从源头关闭炎症，重置免疫系统平衡 [21] - **口服小分子**：为口服药物，避免了单克隆抗体因蛋白质从活跃结肠泄漏带来的挑战，具有良好且可预测的药代动力学吸收和特征 [22] 未来展望 - **维护试验**：44周的METINOUS试验无时间风险，将于2026年第二季度公布结果 [18] - **克罗恩病研究**：基于药物作用机制，有理由相信其在克罗恩病治疗中也会有良好效果，但需进一步研究验证 [39][42] - **组合疗法**：公司正在进行多种化合物的临床前组合试验，有望在年底报告IL - 23和alpha - four beta - seven的临床前结果 [57][58] 其他重要但是可能被忽略的内容 - **研究局限性**：公司仅获取数据集几天，尚未完成详尽的二次数据分析，部分亚组分析将留作在即将召开的国际会议上展示 [4] - **患者群体差异**：Apec 2中随机分配到25毫克剂量组的患者是所有组中最难治疗的，可能需要超过8周才能达到临床缓解 [15] - **与其他药物对比**：与S1P受体调节剂和JAK抑制剂相比，obafasimod无心脏和眼部相关担忧，安全性更优 [49][50] - **资金需求**：公司短期内需要筹集资金，目标是为公司提供资金直至2026年第二季度维护试验结果公布，并预留一定缓冲资金，约2亿美元 [83]

Evolution of Leadership Supports SEI's Transformation and Commitment to Long-term GrowthOAKS, Pa., July 22, 2025 /PRNewswire/ -- SEI® (NASDAQ:SEIC) today announced that Karin Risi and Tom Naratil have been appointed to its Board of Directors, effective immediately. They join Executive Chairman Alfred P. West, Jr. and current directors Jonathan Brassington, William Doran, Carl Guarino, CEO Ryan Hicke, Kathryn McCarthy, and Carmen Romeo. Stephanie Miller has resigned as a member of SEI's Board of Directors, e ...

Opendoor Technologies (OPEN -10.75%) shares declined 10.28% Tuesday, closing at $2.88 amid extraordinary volatility that triggered a temporary trading halt midday. The stock faced significant selling pressure after Monday's dramatic 95% surge. When trading resumed following the circuit-breaker halt, Opendoor continued its downward trajectory from its $3.89 opening price, though the trading suspension likely prevented even steeper declines.The broader market remained relatively flat, with the S&P 500 edging ...

VICTORIA, British Columbia, July 22, 2025 (GLOBE NEWSWIRE) -- Eupraxia Pharmaceuticals Inc. (“Eupraxia” or the “Company”) (NASDAQ:EPRX) (TSX:EPRX), a clinical-stage biotechnology company leveraging its proprietary DiffuSphere™ technology designed to optimize local, controlled drug delivery for applications with significant unmet need, today announced that the Company’s management team will present and participate at the following upcoming investor conferences: Canaccord Growth 45th Annual Growth ConferenceD ...

Second-quarter highlights Orders of $7.0 billion, including $3.5 billion of IET orders.RPO of $34.0 billion, including record IET RPO of $31.3 billion.Revenue of $6.9 billion, down 3% year-over-year.Attributable net income of $701 million.GAAP diluted EPS of $0.71 and adjusted diluted EPS* of $0.63.Adjusted EBITDA* of $1,212 million, up 7% year-over-year.Cash flows from operating activities of $510 million and free cash flow* of $239 million.Returns to shareholders of $423 million, including $196 million of ...

HOUSTON, July 22, 2025 (GLOBE NEWSWIRE) -- Intuitive Machines, Inc. (Nasdaq: LUNR) (“Intuitive Machines”) (“Company”) announced today that it will release its financial results for the second quarter of 2025 on Thursday, August 7, 2025, before the market opens. Following the news release, the Company will host a conference call the same day at 8:30 am ET to discuss the results. To participate in the call, please dial (800) 715-9871 (USA & Canada) or (646) 307-1963 (International) and reference Conference ID ...

Expected to approximately quintuple Two Trees’ spirits production capacityGREEN COVE SPRINGS, Fla., July 22, 2025 (GLOBE NEWSWIRE) -- MDWerks, Inc. (“MDWerks” or the “Company”) (OTCQB: MDWK), a forward-thinking company leading the charge in the world of sustainable technology, today announced that its subsidiary, Two Trees Beverage Company (“Two Trees”), is planning to install a second Spirits Rapid Aging System (“SRAS”) at its Fletcher, North Carolina facilities in August 2025 due to steady demand and proj ...

Châtillon, France, July 22, 2025 DBV Technologies Announces Appointment of James Briggs as Chief Human Resources Officer DBV Technologies (Euronext: DBV – ISIN: FR0010417345 – Nasdaq Market: DBVT), a clinical-stage biopharmaceutical company, today announced the appointment of James Briggs as its Chief Human Resources Officer, succeeding Caroline Daniere. An experienced human capital executive, James will lead key initiatives as DBV transitions from a development-stage biotechnology company to a potential c ...

Vancouver, British Columbia--(Newsfile Corp. - July 22, 2025) - At the request of CIRO, InsuraGuest Technologies Inc. (TSXV: ISGI) (OTCQB: ISGIF) ("InsuraGuest" or the "Company") wishes to confirm that the Company's management is unaware of any material change in the Company's operations that would account for the recent increase in market activity. InsuraGuest Technologies Inc. is an innovative Insurtech company. The Company delivers insurance and/or warranty program coverages to vacation rentals, hotels, ...