Key Takeaways QURE stock soared 247.7% after AMT-130 met primary and secondary endpoints in Huntington's disease study.High-dose AMT-130 slowed disease progression by 75% on cUHDRS and 60% on TFC at 36 months.AMT-130 showed dose-dependent benefits on motor and cognitive function with a manageable safety profile.Shares of uniQure N.V. (QURE) skyrocketed 247.7% on Wednesday after the company reported meeting key goals in the pivotal early to mid-stage study of its investigational gene therapy, AMT-130, for th ...

NEW YORK, Sept. 25, 2025 (GLOBE NEWSWIRE) -- Attorney Advertising--Bronstein, Gewirtz & Grossman, LLC, a nationally recognized law firm, notifies investors that a class action lawsuit has been filed against Jasper Therapeutics, Inc. (“Jasper” or “the Company”) (NASDAQ: JSPR) and certain of its officers. Class Definition This lawsuit seeks to recover damages against Defendants for alleged violations of the federal securities laws on behalf of all persons and entities that purchased or otherwise acquired Jasp ...

Faruqi & Faruqi, LLP Securities Litigation Partner James (Josh) Wilson Encourages Investors Who Suffered Losses In Cytokinetics To Contact Him Directly To Discuss Their Options If you purchased or acquired securities in Cytokinetics between December 27, 2023 and May 6, 2025 and would like to discuss your legal rights, call Faruqi & Faruqi partner Josh Wilson directly at 877-247-4292 or 212-983-9330 (Ext. 1310). [You may also click here for additional information] NEW YORK, Sept. 25, 2025 (GLOBE NEWSWIRE) - ...

**公司及行业** * 公司为Moderna 专注于利用mRNA平台开发肿瘤治疗产品[1][5][27] * 行业涉及肿瘤免疫治疗 包括个体化新抗原疗法、现成癌症抗原疗法、T细胞衔接器、细胞疗法增强剂和体内细胞疗法[5][11][17][21] **核心观点与论据** * **个体化新抗原疗法(INT/mRNA-4157)临床效益显著** 在辅助黑色素瘤III期研究中与Keytruda联用可将患者癌症复发或死亡风险降低49% 远处转移风险降低62%[6][7] * **安全性表现突出** 所有肿瘤抗原疗法均显示良好耐受性 与Keytruda联用未出现额外安全性问题[7][14] * **现成癌症抗原疗法采用"即用型"设计** mRNA-4359靶向PD-L1和IDO蛋白 适用于多种癌症类型 预计2024年10月ESMO公布与Keytruda联用的ARM1B数据[11][12][13] * **T细胞衔接器平台具有多重靶向优势** 可同时靶向三个表面抗原(mRNA-2808) 并通过mRNA平台提供共刺激信号 增强T细胞活性和特异性[18][19] * **细胞疗法增强剂可改善实体瘤疗效** mRNA-4203设计用于增强Immatics的体外TCRT疗法(IMA203) 通过编码相同抗原来提升工程化T细胞反应[21][23][24] **其他重要内容** * **关键研发里程碑明确** 2026年将公布INT五年随访数据和III期辅助黑色素瘤研究结果 2024年10月ESMO公布mRNA-4359的ARM1B数据[6][9][13][39] * **开发策略系统化** 从高肿瘤突变负荷(黑色素瘤)到低突变负荷癌症 从早期辅助设置到晚期转移设置进行方法学探索[43][44] * **合作伙伴关系策略多样** 与默克(Merck)就INT项目达成50/50成本与利润共享合作 与Immatics合作开发T细胞衔接器靶向细胞内抗原[60] * **平台技术优势明显** mRNA平台可实现多重靶向(最多三个抗原) 并能够编码共刺激蛋白 相比重组蛋白方法具有差异化优势[18][19] * **竞争格局存在差异** BioNTech的iNEST使用20个新抗原和静脉输注脂质复合物 IO Biotech的肽疫苗虽错过统计学显著性但验证了PD-L1/IDO靶点的生物学假设[51][52][53]

Faruqi & Faruqi, LLP Securities Litigation Partner James (Josh) Wilson Encourages Investors Who Suffered Losses In Jasper To Contact Him Directly To Discuss Their Options If you purchased or acquired securities in Jasper between November 30, 2023 and July 3, 2025 and would like to discuss your legal rights, call Faruqi & Faruqi partner Josh Wilson directly at 877-247-4292 or 212-983-9330 (Ext. 1310). [You may also click here for additional information] NEW YORK, Sept. 25, 2025 (GLOBE NEWSWIRE) -- Faruqi & ...

To ensure this doesn’t happen in the future, please enable Javascript and cookies in your browser.If you have an ad-blocker enabled you may be blocked from proceeding. Please disable your ad-blocker and refresh. ...

Entrada Therapeutics (NasdaqGM:TRDA) Update / Briefing September 25, 2025 10:00 AM ET Company ParticipantsDipal Doshi - CEOConference Call ParticipantsRam Selvaraju - Managing Director and AnalystRam SelvarajuI'm joined by Dr. Salva Raggio. I'm a Managing Director and Senior Healthcare Equity Research Analyst here within the Equity Research Department at H.C. Wainwright & Company. I'm joined today by Dipal Doshi, Chief Executive Officer of Entrada Therapeutics. Entrada is traded on the Nasdaq under the tick ...

Question-and-Answer SessionMichael RyskinBofA Securities, Research Division Format will be a fireside chat, but feel free to raise your hand, and we'll let you jump in. John, maybe to kick things off a little bit. We're about 3/4 of the way through the year. Can we take a step back and sort of review how the year has played out so far relative to your initial expectations? Maybe what have been the biggest surprises, both upside or downside? ...

业绩总结 - mRNA-4157/V940与KEYTRUDA联合使用的复发无生存率为74.8%，而KEYTRUDA单独使用为55.6%[12] - 在34.9个月的中位随访中，mRNA-4157/V940与KEYTRUDA联合使用降低复发或死亡风险49%[14] - 在约3年的随访中，mRNA-4157/V940与KEYTRUDA联合使用在远处转移无生存率方面显示出62%的风险降低[17] 用户数据 - mRNA-4157/V940与KEYTRUDA联合使用的治疗相关不良事件发生率为100%，而KEYTRUDA单独使用为82%[18] - mRNA-4157/V940在与KEYTRUDA联合使用时，34.6%的患者出现3级及以上不良事件，而KEYTRUDA单独使用为36%[18] 未来展望 - mRNA-4157/V940的临床试验在2026年将提供5年随访数据[11] - mRNA-4157/V940的III期试验已完全招募，参与者约为1,089人[21] - mRNA-4359正在进行的I/II期研究中，计划招募更多适应症[27] - mRNA-4203的I期研究设计为剂量递增，已对15名患者进行给药[51]

My latest coverage of Cassava Sciences (NASDAQ: SAVA ) following the company’s reporting of a first failure of its drug program for Alzheimer’s disease. The company has meanwhile moved away from Alzheimer’s disease, and isI am a long-term investor focused on growth markets, AI and biotech opportunities in my more volatile portfolio. I try to look for undervalued and under-the-radar stocks with serious potential and good scientific or other background. My ambition here is to cover stocks with considerable gr ...