文章核心观点 公司提交AX - 0810的临床试验申请，标志Axiomer RNA编辑平台和管线进入临床开发阶段，首个人体试验将评估其安全性等，预计2025年Q4出初始数据 [1][2][8] 相关目录总结 公司进展 - 公司向欧洲药品管理局提交AX - 0810的临床试验申请，拟开展1期临床试验 [1] - 若获监管批准，1期研究预计在荷兰单一地点开展，2025年Q4出初始数据 [2] AX - 0810介绍 - AX - 0810是研究性GalNac递送的RNA编辑寡核苷酸，通过靶向NTCP治疗胆汁淤积性肝病 [3] - 其作用机制是选择性调节NTCP功能，减少胆汁酸再摄取，有人类遗传学数据支持 [3] Axiomer™介绍 - Axiomer™是下一代RNA碱基编辑技术，利用人体细胞中的ADAR介导RNA单核苷酸变化 [4] - Axiomer EONs可纠正致病突变的RNA，调节蛋白表达或赋予蛋白新功能 [4] 公司介绍 - 公司致力于通过变革性RNA疗法改善生活，基于独特RNA修复平台技术拓展管线 [5]

文章核心观点 - 公司宣布2025年第二季度备忘录在其网站“投资者”页面可供查看 [1] 关于公司 - 公司是全球生物制药领导者，运营涵盖创新全领域，为全球患者提供药物 [3] - 公司有超120年历史，致力于改善健康的承诺从未动摇 [3] - 公司全球网络使57个市场的37000名员工能开发未来药物，推动仿制药和生物制剂生产 [3] 关于备忘录 - 公司准备该文件以协助季度财务建模，基于公司过往业绩、管理层对业务前景的评论及部分独立来源数据 [2] 联系方式 - 媒体咨询邮箱为TevaCommunicationsNorthAmerica@tevapharm.com [5] - 投资者关系咨询邮箱为TevaIR@Tevapharm.com [5]

ATHENS, Greece, June 26, 2025 (GLOBE NEWSWIRE) -- TOP Ships Inc. (the “Company” or “TOP Ships”) (NYSE American: TOPS), an international owner and operator of modern, fuel-efficient “ECO” tanker vessels, announced today that the application of Rubico Inc. (“Rubico”), to list its common shares on the Nasdaq Capital Market has been approved. In addition, the registration statement on Form 20-F filed by Rubico in connection with its spin-off from Top Ships Inc has been declared effective by the U.S. Securities ...

TORONTO, June 26, 2025 (GLOBE NEWSWIRE) -- New Horizon Aircraft (NASDAQ: HOVR), doing business as Horizon Aircraft (“Horizon Aircraft” or the “Company”), an advanced aerospace engineering company and developer of one the world’s first hybrid eVTOL (electric Vertical Take-Off and Landing) aircraft, announced today that it received notice from The Nasdaq Stock Market that the Company has regained compliance with the Nasdaq Capital Market’s minimum bid requirement in Listing Rule 5550(a)(2) and that the matter ...

RAPID CITY, S.D., June 26, 2025 (GLOBE NEWSWIRE) -- Black Hills Corp. (NYSE: BKH) today announced the release of its 2024 Corporate Sustainability Report, showcasing the company’s continued commitment to a resilient energy future through safe, reliable and cost-effective energy solutions. “For 141 years, we’ve powered progress through the delivery of electricity and natural gas. Today, our sustainability efforts are integrated into every part of our business,” said Linn Evans, president and CEO of Black Hil ...

Singapore, June 26, 2025 (GLOBE NEWSWIRE) -- Basel Medical Group Ltd (Nasdaq: BMGL) (the “Company”), today announced that Cathay Securities, Inc., as the representative of the several underwriters of the Company’s initial public offering, has granted its consent on June 23, 2025 to the lock-up provision in the underwriting agreement dated February 24, 2025, permitting (i) a public offering or private placement of new securities of the Company, and (ii) the filing with the U.S. Securities and Exchange Commis ...

SEATTLE, June 26, 2025 (GLOBE NEWSWIRE) -- Trupanion, Inc. (Nasdaq: TRUP), a leader in medical insurance for cats and dogs, will host its Annual Investor Day on Wednesday, September 17, 2025. This annual event is designed to be the best opportunity for Trupanion shareholders and guests to understand Trupanion’s achievements and challenges over the past year and its strategic vision going forward. Management remarks are expected to commence shortly after 9:00 am Pacific Time. The event will feature presentat ...

ST. LOUIS, June 26, 2025 (GLOBE NEWSWIRE) -- Stifel Financial Corp. (NYSE: SF) today reported selected operating results for May 31, 2025, in an effort to provide timely information to investors on certain key performance metrics. Due to the limited nature of this data, a consistent correlation to earnings should not be assumed. Ronald J. Kruszewski, Chairman and Chief Executive Officer, said, “In May, recruiting and market appreciation drove a 3% increase in total client assets and a 4% increase in fee-bas ...

MARLBOROUGH, Mass. and YOKNEAM ILLIT, Israel, June 26, 2025 (GLOBE NEWSWIRE) -- Lifeward Ltd. (NASDAQ: LFWD) (“Lifeward” or the “Company”), a global leader in innovative medical technology to transform the lives of people with physical limitations or disabilities, today announced the closing of its previously announced public offering of an aggregate of 4,000,000 of the Company’s ordinary shares and accompanying warrants to purchase up to 4,000,000 of the Company’s ordinary shares, at a combined public offe ...

文章核心观点 挪威邮轮控股有限公司成功将现有高级有担保循环信贷额度从17亿美元扩大至24.86亿美元，增强了公司流动性，有助于优化资本结构和支持长期增长 [1][2] 公司业务情况 - 公司是全球领先的邮轮公司，旗下运营挪威邮轮、大洋洲邮轮和七海丽晶邮轮三个品牌 [3] - 公司拥有33艘邮轮，约70050个床位，提供前往全球约700个目的地的航线 [3] - 公司预计到2036年将为三个品牌新增12艘邮轮，增加超37500个床位 [3] 信贷额度调整 - 公司将现有高级有担保循环信贷额度从17亿美元扩大至24.86亿美元，现有条款和2030年到期日不变 [1] - 信贷额度的扩大增强了公司的流动性，体现了贷款合作伙伴对公司战略和业绩的持续信心 [2] - 增强的循环信贷额度为公司执行战略优先事项提供更大灵活性，支持长期增长轨迹 [2]