Start Time: 16:30 January 1, 0000 5:19 PM ET Zymeworks Inc. (NASDAQ:ZYME) Q4 2021 Earnings Conference Call February 24, 2022, 16:30 PM ET Company Participants Kenneth Galbraith - Chair and CEO Chris Astle - SVP and CFO Neil Klompas - COO Neil Josephson - CMO Jack Spinks - Manager of IR Conference Call Participants Yigal Nochomovitz - Citigroup Akash Tewari - Jefferies Operator Thank you for standing by. This is the conference operator. Welcome to the Zymeworks Fourth Quarter and Year-End Results Conference ...

zymeworks JP Morgan 2022 Healthcare Conference Neil Klompas, COO & CFO NYSE: ZYME Zymeworks Inc www.zymeworks.com 2 Legal Disclaimer This presentation includes "forward-looking statements" within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and "forward-looking information" within the meaning of Canadian securities laws, or collectively, forward looking statements. Forward-looking statements include statements that may relate to our plans, objectives, goals, strategies, future ev ...

zymeworks Jefferies London Healthcare Conference Presentation November 18th – 19th Ali Tehrani - President & CEO www.zymeworks.com NYSE: ZYME Undergoing Transformation En Route Towards Commercialization 2023 2024 2025 2026 Biliary Tract BLA Second-Line üFast-to-Market Strategy üSingle-agent, single-arm üUS Accelerated Approval Gastroesophageal sBLA First-Line ü Expand Strategy ü Zani + Chemo ± PD1 Biliary Tract sBLA First-Line ü Expand Strategy ü Zani + Chemo (± PD11) 3 BLAs in Gastrointestinal Cancers in N ...

zymeworks Making Therapies that Make a Difference CORPORATE OVERVIEW NYSE: ZYME 2021 Bloom Burton & Co. Healthcare Investor Conference www.zymeworks.com 2 Legal Disclaimer This presentation includes "forward-looking statements" within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and "forward-looking information" within the meaning of Canadian securities laws, or collectively, forward looking statements. Forward-looking statements include statements that may relate to our plans, o ...