WEST PALM BEACH, FLORIDA, July 31, 2025 (GLOBE NEWSWIRE) -- FOXO Technologies, Inc., (NYSE American: FOXO) (“FOXO” or the “Company”) today announced that its behavioral health subsidiary, Myrtle Recovery Centers, Inc., has renewed its operating license for its Oneida, TN location for another year. The license renewal to operate an alcohol and drug residential treatment facility was granted by the State of Tennessee’s Department of Mental Health and Substance Abuse Services after a successful annual inspecti ...

文章核心观点 公司2025年第二季度和上半年业绩表现强劲，RUCONEST®和Joenja®收入增长显著，运营利润转正，基于良好表现上调全年收入指引；公司在业务战略执行上取得进展，包括产品上市、提交监管申请、推进临床试验等；虽面临美国关税影响，但预计对业务无重大影响；未来将继续推进产品研发和市场拓展，有望实现持续增长 [2][4][5] 分组1：财务亮点 第二季度（2025年） - 收入增长26%，达9320万美元，RUCONEST®收入8040万美元，增长28%，Joenja®收入1280万美元，增长15% [7][29][30] - 毛利润增长27%，达8420万美元，运营利润1080万美元，去年同期亏损310万美元 [30][31] - 净财务结果亏损400万美元，去年同期盈利340万美元，净利润460万美元，去年同期亏损120万美元 [32][33] - 运营活动产生现金1170万美元，现金及等价物增至1.308亿美元 [34] 上半年（2025年） - 总收入增长33%，达1.723亿美元，RUCONEST®收入1.49亿美元，增长37%，Joenja®收入2330万美元，增长13% [35] - 毛利润增长37%，达1.55亿美元，运营利润380万美元，去年同期亏损1940万美元 [36][37] - 净财务结果亏损850万美元，去年同期盈利360万美元，净亏损1030万美元，去年同期亏损1370万美元 [38][39] - 运营活动产生现金1200万美元，现金及等价物较去年底减少3860万美元至1.308亿美元 [40] 分组2：商业化资产 RUCONEST® - 2025年第二季度收入8040万美元，增长28%，上半年收入1.49亿美元，增长37% [6] - 美国市场需求强劲，第二季度销量增长27%，上半年增长31% [8] Joenja® - 2025年第二季度收入1280万美元，增长15%，上半年收入2330万美元，增长13% [9] - 美国市场贡献92%的二季度收入，6月底美国付费治疗患者达114人，增长25% [10][11] - 4月在英国上市，首批患者已接受商业治疗 [12] 分组3：APDS患者发现与VUS患者重新分类 APDS患者发现 - 截至6月30日，全球确诊APDS患者971人，其中美国257人，165人符合Joenja®治疗条件 [13] VUS患者重新分类 - 美国超1400名VUS患者，研究支持将其重新分类为APDS患者，预计下半年推动Joenja®患者增长 [14][15] - 研究表明APDS实际患病率可能比之前估计高100倍，公司将开展研究扩大Joenja®可治疗患者群体 [16] 分组4：产品研发进展 Joenja®（leniolisib） - 计划三季度向FDA提交治疗4 - 11岁APDS儿童的补充新药申请，预计2026年上半年获批 [19] - 6月向日本PMDA提交治疗4岁及以上APDS患者的新药申请，预计9个月内获批 [20] - 按计划完成EMA对leniolisib治疗12岁及以上APDS患者营销授权申请的相关生产活动，预计2026年1月前提交回复 [21] - 两项针对其他原发性免疫缺陷病（PIDs）的II期临床试验进展顺利，预计2026年有结果 [22] KL1333 - 用于线粒体DNA驱动的原发性线粒体疾病的关键临床试验进行中，预计2027年有结果，2028年底可能获FDA批准 [23] - FALCON临床试验按计划推进，新增临床站点，第二批患者已给药 [24] 分组5：业务收购与组织更新 收购Abliva AB - 2025年2月14日至6月18日，收购Abliva剩余11.1%股份，实现100%控股 [25][68] 组织更新 - 5月宣布计划将一般及行政费用降低15%或1000万美元，工作按计划推进 [26] 分组6：展望与总结 - 2025年预计总收入3.35 - 3.5亿美元，运营费用3.04 - 3.08亿美元 [44] - 在美国寻找更多APDS患者，推动患者接受Joenja®付费治疗，增加美国以外leniolisib收入 [44] - 推进leniolisib更多监管批准，推进PIDs和KL1333临床试验，关注罕见病临床阶段机会的收购和授权引进 [44]

Janux Therapeutics (NASDAQ: JANX )’s know-how and scientific development have raised a lot of interest among investors, as well as numerous buy-out rumors. Although I would not discard the possibility of a buyout, I want to center my analysisOriginally a Biologist, M.Sc in Biomedicine, PhD in Bioengineering, with +20 years experience in the research and development of novel Cell & Gene Therapies (CGT) tackling several clinical needs. As an investor, I have been utilising my background in life sciences to as ...

TORONTO, July 30, 2025 (GLOBE NEWSWIRE) -- Revive Therapeutics Ltd. (“Revive” or the “Company”) (OTCQB: RVVTF) (CSE: RVV) (FRANKFURT: 31R), a specialty life sciences company dedicated to developing innovative therapeutics for critical medical needs, announces that it is proposing to arrange a private placement offering of up to 30,952,381 units, at a price of $0.021 per unit, for gross proceeds to Revive of up to $650,000, and to settle $67,400 owing pursuant to an arm’s length note payable by the issuance ...

For the quarter ended June 2025, Guardant Health (GH) reported revenue of $232.09 million, up 31% over the same period last year. EPS came in at -$0.44, compared to -$0.48 in the year-ago quarter.The reported revenue compares to the Zacks Consensus Estimate of $211.43 million, representing a surprise of +9.77%. The company delivered an EPS surprise of +15.38%, with the consensus EPS estimate being -$0.52.While investors scrutinize revenue and earnings changes year-over-year and how they compare with Wall St ...

NEW YORK, July 30, 2025 /PRNewswire/ --Why: Rosen Law Firm, a global investor rights law firm, reminds purchasers of securities of PepGen Inc. (NASDAQ: PEPG) between March 7, 2024 and March 3, 2025, both dates inclusive (the "Class Period"), of the important August 8, 2025 lead plaintiff deadline.So What: If you purchased PepGen securities during the Class Period you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement.What to do next: To j ...

Neurocrine Biosciences (NBIX) Q2 2025 Earnings Call July 30, 2025 04:30 PM ET Company ParticipantsTodd Tushla - VP - IRKyle Gano - President, CEO & DirectorMatt Abernethy - CFOEric Benevich - CCOSanjay Keswani - Chief Medical OfficerPhilip Nadeau - MD, Health Care – BiotechnologyEiry Roberts - Strategic Advisor to CEO - (CMO Emerita)Paul Matteis - Managing Director, Head of Therapeutics ResearchCory Kasimov - Senior Managing DirectorBrian Abrahams - MD & Co-Head of Biotechnology ResearchCorinne Johnson - Vi ...

Guardant Health (GH) Q2 2025 Earnings Call July 30, 2025 04:30 PM ET Speaker0Good afternoon, and thank you for attending the Guardant Health Q2 twenty twenty five Earnings Conference Call. My name is Jayson and I'll be the moderator today. All lines will be muted during the presentation portion of the call and an opportunity for questions and answers at the end. I would now like to pass the conference over to your host, Zarek Hirshid.Speaker1Thank you. Earlier today, Guardant Health released financial resul ...

Neurocrine Biosciences (NBIX) Q2 2025 Earnings Call July 30, 2025 04:30 PM ET Speaker0Good day, everyone, and welcome to today's Neurocrine Biosciences Second Quarter twenty twenty five Results Conference. At this time, all participants are in a listen only mode. Later, you will have the opportunity to ask questions during the question and answer session. You may register to ask a question at any time by pressing star one on your telephone keypad. Please note this call may be recorded and I will be standing ...

NEW YORK, July 30, 2025 (GLOBE NEWSWIRE) -- WHY: Rosen Law Firm, a global investor rights law firm, reminds purchasers of securities of Sarepta Therapeutics, Inc. (NASDAQ: SRPT) between June 22, 2023 and June 24, 2025, both dates inclusive (the “Class Period”), of the important August 25, 2025 lead plaintiff deadline. SO WHAT: If you purchased Sarepta securities during the Class Period you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangeme ...